Resilience of Global Supply Chains and Generic Drug Shortages DRAFT
Abstract
Since 2009, U.S. hospitals have faced chronic shortages of generic (off-patent) injectable drugs, defying theexpectation that competitive pressures would quickly resolve excess demand in this commodity-like market. Over the same period, production of generic drugs shifted dramatically to the Global South. I document the causal impact of offshore facilities on U.S. shortages by constructing a novel dataset that maps the exact manufacturing location of injectable drugs sold in the U.S., thereby resolving pervasive traceability issues in globalized pharmaceutical supply chains. Drugs produced by Asian manufacturing plants face a 54 percentage-point higher probability of shortages compared to their U.S. counterparts, with shortages lasting 130 days longer on average. To shed light on the incentive mechanisms behind supply disruptions, I then develop and estimate a partial-equilibrium model of global procurement in which manufacturers trade off cost-cutting and reliability investments, endogenously translating into higher shortage risks in offshore locations. I estimate the model by GMM to recover location‑specific disruption probabilities, demand and cost parameters, finding that hospital buyers place no weight on manufacturers' shortage history. Offshoring enables drug manufacturers to exploit laxer regulatory oversight and target higher disruption risks than permissible in the U.S., in exchange for lower production costs. The resulting increase in supply disruption risk, combined with price stickiness and lumpy production capacity in generic injectable markets, generates persistent shortage spells once production globalizes. Counterfactual simulations reveal that reshoring subsidies result in substantial price increases with limited consumer welfare gains. Spot-price increases during shortages fail to significantly increase consumer surplus as they do not address lumpy capacity adjustments. In contrast, enforcing failure-to-supply penalties in contracts improves consumer surplus by raising manufacturers' expected cost of a disruption, inducing ex-ante reliability investments and reducing shortage spells. Sharp reductions in patients forced into the outside option result in large welfare gains that are not offset by the associated price increases.
Urban Migration, Health Amenities, and Local Newspapers in 1870-1940 U.S., with Quan Le [Draft and Slides available upon request]
Abstract
We study the role of newspapers in the migration decisions of rural individuals in the 1870-1940 United States. Contributing to the urban and health economics literature, we offer new insights about how information, specifically newspaper portrayals of public health advancements like water filtration and sewage systems, shapes rural-urban migration patterns. We show that access to information about urban health conditions through newspapers played a crucial role in encouraging rural individuals to move to cities over the turn of the 20th century. By exploiting a novel linkage between full-count U.S. census data and a unique historical newspaper dataset at the county level, which leverages text-mining and Natural Language Processing (NLP) algorithms, we provide novel evidence that rural individuals responded to newspaper narratives on public health investments and disease occurrences. Rural migrants with access to information about public health investments migrated in higher proportion to sanitation-adopting cities compared to rural migrants with no access to such information, and avoided cities affected by epidemics more than their non-informed counterparts. This finding is consistent with the literature suggesting that such investments significantly reduced mortality from waterborne diseases (typhoid and diphtheria) and improved quality of life, making cities more attractive places to live. As policymakers consider strategies to revitalize urban areas in the post-pandemic era, our study highlights the potential importance of information dissemination in promoting urban growth and development.
Making Talk Cheap: LLMs and Signaling on Digital Labor Platforms, with Jesse Silbert [Draft and Slides available upon request]
Abstract
Large language models have the potential to transform the landscape of online labor marketplaces, not just through the channels of supply and demand but also the matching technology itself. In this paper, we use data from Freelancer.com, a major online labor platform, to investigate exactly how the advent of large language models (LLMs) affects the matching process in online labor markets. Our first major contribution is to develop a new measure of “content fit” that uses a LLM to quantify how well a cover letter responds to a given job description. We show that this measure is significantly predictive of labor demand, and that job posters have a high willingness to pay for increases in the “content fit” of cover letters. Motivated by this finding, we develop a Spence (1973) style model of signaling, in which Freelancers spend time (costly effort) to increase their cover letters’ levels of “content fit”, and the freelancers with a greater match quality with a given job posting are more easily (less marginally costly) able to expend that effort. This model along with our descriptive findings lend evidence to the theory that job posters are using “content fit” as a noisy but predictive signal of freelancer match quality. With this theory in hand, we then ask what happens to the efficiency of this signaling equilibrium when LLMs make it cheaper to increase “content fit”, thus garbling the signal. To do so, we estimate how the relationship between time spent writing and “content fit” changes after the introduction of LLMs onto the platform, and then simulate a signaling equilibrium, in which supply and demand are held fixed as they are in the pre-LLM time periods, but the signaling technology of the post-LLM time periods is used instead. One of our key contributions is to develop estimation and identification strategies of scoring auctions where one of the dimensions of the score is a signal for quality whose weighting in the score is determined by the equilibrium itself. These strategies allow us to recover both supply and demand, as well as the relevant parameters of the signaling equilibrium.
Regulatory Divergences, Product Differentiation and Re-routing of Output : Evidence from the Pharmaceutical Industry
Abstract
Enforcement of quality regulations in the Global North may decrease the quality of goods distributed to the Global South, due to the rerouting by manufacturers of "sub-quality" products to less regulated markets. This paper studies the global redistribution of products recalled in highly regulated markets, such as the United States and Europe, when the manufacturers are global firms. Are new global manufacturing forces differentially allocating their products based on differentials in regulatory enforcement among destination markets? To answer these questions, I digitized new U.S. data on pharmaceutical product recalls and warning letters to foreign manufacturing facilities, which I merge with detailed descriptions extracted from Indian customs manifests. Using text mining techniques, I trace global exports of drug produced by Indian drug manufacturers and study what happens to global exports after an Indian product is recalled in the U.S. After a recall, I find evidence that firms reduce U.S. sales and reallocate production to other (less regulated) markets, such as African and South-Asian markets. Such behavior may result in an equilibrium in which high-quality products are traded with the North and sub-optimal quality products are diverted to the South. This may have important policy implications if more stringent quality enforcement in the North widens the differential in regulatory standards with the South. Abilities for global manufacturers to arbitrage exports based on differentials in global regulatory standards may lead to more product differentiation, resulting in lower-quality batches of products being sent to South countries with less regulated markets. This may also have implications for product availability in the North, as suppliers now located in the South may have lower incentives to quickly correct manufacturing quality issues if they can still distribute these products to South markets.
Search and Matching in Digital Markets for Trade-in-Tasks, with Eduard Boehm, Clement Herman and Jesse Silbert
Pre Ph.D. work
An Indicator for Statistical Literacy Based on National Newspaper Archives (w Thilo Klein & El Iza Mohamedou). OECD Working Paper
Trading News: International Trade and Endogenous Characteristics in Digital New Markets [Draft available upon request]
Abstract
This paper provides a first empirical study of how openness to international trade in news products, a phenomenon largely facilitated by the digitalization of newspapers, may impact the characteristics of the information products available to consumers. Based on a case study of the entry of French media firms in Francophone Africa, I build a new dataset of more than 800 000 newspaper articles over the period 2005 to 2017. Using text mining techniques, I construct a five-dimensional set of newspaper characteristics to qualitatively analyze newspaper data. My evidence suggests that the entry of French digital newspapers, which produce a relatively low share of local news and whose websites are generally uniformly targeting all Francophone African countries, lead to a significant decrease of the diversity of subjects treated by Francophone African newspapers, characterized by a strong and significant increase of the share of local news, and a small decrease of the total number of articles related to France. I also find a slight but significant impact of the penetration of French digital newspapers on two indicators of newspaper format, namely a small increase of the average frequency of publication of Francophone African newspapers, and a very small decrease of the mean wordcount per articles.